hematologic

Erythrocytosis (Elevated RBC/Hematocrit on TRT)

Definition

Erythrocytosis refers to an abnormal increase in red blood cell mass, and is the most common adverse effect of TRT affecting up to 40% of patients. Testosterone directly stimulates erythropoietin (EPO) production in the kidneys, driving red cell synthesis. Secondary erythrocytosis from TRT is distinct from primary polycythemia vera but carries similar thrombotic risk when hematocrit exceeds 52–54%.

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