Estrogen rebound is a rapid rise in estradiol following abrupt discontinuation of an aromatase inhibitor (AI). During AI use, aromatase is suppressed and estradiol is low. When the AI is stopped, aromatase activity rapidly normalizes while testosterone levels may temporarily be at their highest point, resulting in a sudden surge in aromatization and estradiol that can overshoot baseline.
GearCheck connects glossary concepts to your actual bloodwork — showing exactly where your values sit and what they mean in the context of your protocol.
Analyze My Bloodwork →GearCheck provides blood marker analysis and harm reduction education. Information is for educational purposes only and does not constitute medical advice. Always consult a healthcare professional.