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Thyroid Function on AAS

Definition

AAS can suppress thyroid function through several mechanisms: reducing TBG (thyroid binding globulin) which artificially lowers measured total T4/T3, suppressing TRH/TSH secretion at high doses, and potentially causing direct pituitary effects. However, many athletes on AAS have subclinical hypothyroidism that predates AAS use and becomes symptomatic under the metabolic demands of training.

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