AST is an enzyme found in both liver and muscle tissue. On TRT and injectable AAS, AST elevation is often of skeletal-muscle origin (training-related) rather than hepatic, making ALT/AST ratio and GGT critical for distinguishing true liver stress.
Oral 17-alpha alkylated AAS (oxandrolone, stanozolol, oxymetholone) cause genuine hepatotoxicity with parallel AST and GGT elevation; injectable testosterone typically raises AST via muscle breakdown without liver damage.
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Analyze My Bloodwork →GearCheck provides blood marker analysis and harm reduction education. Information is for educational purposes only and does not constitute medical advice. Always consult a healthcare professional.