hepatic

Hepatotoxicity (Liver Toxicity from Oral AAS)

Definition

Hepatotoxicity from oral anabolic steroids results from the 17-alpha alkylation (17-AA) modification that allows these compounds to survive first-pass hepatic metabolism. This modification impairs normal hepatocyte function, blocks bile secretion (cholestasis), and in severe or prolonged cases can cause peliosis hepatis (blood-filled cysts), hepatic adenomas, or hepatocellular carcinoma.

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Frequently Asked Questions

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