renal

Creatinine vs Cystatin C as Renal Markers

Definition

Creatinine is the standard marker of kidney function but is produced in proportion to muscle mass, making it unreliable in high-muscle-mass athletes. An athlete with 100 kg of lean mass will have elevated creatinine from muscle turnover alone, triggering false-positive kidney disease screening. Cystatin C is a kidney filtration marker not influenced by muscle mass, making it the superior renal marker for athletes and AAS users.

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